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    【歐盟】評估一種葡聚糖1,4-α-葡萄糖苷酶的安全性

    發布時間:2022-03-11 瀏覽量:112
    2022年3月9日,歐盟食品安全局就一種聚糖1,4-α-葡萄苷酶(glucan 1,4-α-glucosidase )的安全性評價發布意見。
     
      據了解,這種食品酶是由轉基因黑曲霉菌株NZYM-BR生產的,旨在用于生產葡萄糖漿和蒸餾酒精的淀粉加工中。
     
      經過評估,專家小組認為,在預期的使用條件下,不能排除飲食暴露引起過敏和誘發反應的風險,但這種情況發生的可能性很低。根據所提供的數據,小組得出結論,該食品酶在預期的使用條件下不會引起安全隱患。部分原文報道如下:
     

      The food enzyme glucan 1,4-α-glucosidase (4-α-d-glucan glucohydrolase, EC 3.2.1.3) is produced with the genetically modified Aspergillus niger strain NZYM-BR by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in starch processing for the production of glucose syrups and distilled alcohol. Since residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of glucose syrups and by distillation, dietary exposure estimation was considered not necessary. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,135 mg TOS/kg body weight (bw) per day, the highest dose tested. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched for and two matches were found. The Panel considered that under the intended conditions of use (other than distilled alcohol production) the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.



    文章來源:食品伙伴網


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